We are developing innovative drugs for severe asthma
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“TAKC-02” Suppresses both Eosinophilic and Neutrophilic Inflammation
Indications: Steroid-resistant Severe Asthma
An antisense oligonucleotide targeting the mRNA of Mex3B
Mex3B is an RNA binding protein that induces cytokines involved in airway inflammation
Route of administration: inhalation
status: non-clinical
Structure of Gapmer-type antisense oligonucleotide
TAKC-02: Clinical Significance
the first drug for neutrophilic severe asthma
effective for both neutrophilic and eosinophilic severe asthma
TAKC-02 Suppresses both Eosinophilic and Neutrophilic Inflammation
Ref: The RNA Binding Protein Mex-3B Is Required for IL-33 Induction in the Development of Allergic Airway Inflammation Yamazumi et al Cell Rep. 2016 Aug 30;16(9):2456-71.
TAKC-02 Suppresses both Eosinophilic and Neutrophilic Inflammation
